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If your job requires a commute to either Rochester or Buffalo, you might want to call your boss now and tell him or her you won't make it into work today.  That big project you're working on? It will just have to wait.

The Thruway is closed in both directions from from Rochester to Erie, Pa., according to the Thruway Authority web site.  Those are exits 46 to 61.

We have no information on alternative routes at this time, but if the Thruway is closed ... 

UPDATE: 6:24 a.m.: WBTA has more on closings and cancellations.

UPDATE: 6:49 a.m.: Here's the latest weather statement from the National Weather Service:

... SLOW TRAVEL ACROSS THE NIAGARA FRONTIER THIS MORNING...

WHILE THE HEAVY LAKE SNOWS HAVE PUSHED SOUTH... THERE WILL STILL BE AREAS OF REDUCED VISIBILITIES FROM BLOWING SNOW EARLY THIS MORNING. THIS WILL BE ACCOMPANIED BY SOME OCCASIONAL LIGHT SNOW SHOWERS... ESPECIALLY ACROSS ORLEANS AND GENESEE COUNTIES WHERE MORE WIDESPREAD LAKE ONTARIO GENERATED SNOWS WILL BE FOUND.

TEMPERATURES EARLY THIS MORNING WILL BE CLOSE TO 10 DEGREES...

WITH GUSTY WEST WINDS OF 15 TO 30 MPH PRODUCING WIND CHILL VALUES CLOSE TO 10 BELOW ZERO. MOTORISTS SHOULD BE PREPARED FOR SNOW COVERED ROADS AND A LONGER COMMUTE TIME.

ANYONE HEADING OUTDOORS SHOULD ALSO BE DRESSED FOR THE SUB ZERO WIND CHILLS BY COVERING AS MUCH EXPOSED SKIN AS POSSIBLE. DRESSING IN LAYERS IS ALSO SUGGESTED.