Some bands of lake effect snow could drop as much as 18 inches of snow on some parts of Western New York between now and 6 a.m., according to the National Weather Service.
The primary areas for the warning are Orleans and Genesee counties.
Winds are expected to hit 15 to 25 mph. Gusts will be up to 35 mph.
Visibility will be reduced to less than a quarter of a mile at times in some places.
NWS warns of difficult travel conditions during the storm.