Charles R. Lowe, 51, of 8131 E. Main Road, #6, Le Roy, reportedly fell asleep while driving westbound on East Main Street, Village of Le Roy, at a speed of 52 mph in the 30 mph zone.
His vehicle veered from its lane and rear-ended a vehicle paused to turn left onto Wolcott Street. That car then struck another vehicle on East Main Street.
The other two drivers suffered minor injuries.
Lowe was taken by Mercy Flight to Strong Memorial Hospital and was initially in the intensive care unit.
He's also charged with reckless driving, speeding, failure to use designated lane, following too closely and two counts of assault in the third degree and criminal negligence.
Following the accident, Lowe was entrapped in his vehicle and required extrication by the Le Roy Volunteer Fire Department.
The Sheriff's Office Crash Management Team assisted in the investigation.
Lowe was issued an appearance ticket and is due back in Le Roy Town Court on April 27.